Clinical parameters affecting multipotent adult progenitor cells in vitro
نویسندگان
چکیده
منابع مشابه
Donor origin of multipotent adult progenitor cells in radiation chimeras.
Multipotent adult progenitor cells (MAPCs) are bone marrow-derived stem cells that have extensive in vitro expansion capacity and can differentiate in vivo and in vitro into tissue cells of all 3 germinal layers: ectoderm, mesoderm, and endoderm. The origin of MAPCs within bone marrow is unknown. MAPCs are believed to be derived from the bone marrow stroma compartment as they are isolated withi...
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Many stem cell types have been shown to differentiate into endothelial cells (ECs); however, their specification to arterial or venous endothelium remains unexplored. We tested whether a specific arterial or venous EC fate could be induced in human multipotent adult progenitor cells (hMAPCs) and AC133(+) cells (hAC133(+)). In vitro, in the presence of VEGF(165), hAC133(+) cells only adopted a v...
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We recently showed that a rare cell from murine bone marrow, which we termed multipotent adult progenitor cells (MAPCs), can be expanded for >120 population doublings. Mouse (m)MAPCs differentiate into mesenchymal lineage cells as well as endothelium and endoderm, and, when injected in the blastocyst, mMAPCs contribute to most if not all somatic cell lineages including the different cell types ...
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Catherine Verfaillie et al., have filed a patent for a stem cell found in the bone marrow of adults that can develop into every single tissue type in the body. It was thought until now that only embryonic stem cells were able to do this, but experiments detailed in the patent show that the cells, dubbed multipotent adult progenitor cells (MACPs) have the potential to do this. (Patent WO0111011,...
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ژورنال
عنوان ژورنال: Heliyon
سال: 2019
ISSN: 2405-8440
DOI: 10.1016/j.heliyon.2019.e02532